Active Pharmaceutical 98% Pizotifen For Antimigraine CAS 15574-96-6
Pizotylene;Pizothifenum;Pizotifenum;Pizotyline (base and/or
436.7°C at 760 mmHg
7.92E-08mmHg at 25°C
Serotonin antagonist structurally related to Cyproheptadine.
Pizotifen called new degree Semillon, pizotifen malate, is a
chemical synthetic antihistamines, its chemical structure is
similar cyproheptadine and amitriptyline, has strong anti 5-
serotonin and histamine and weak anti acetylcholine effect, one of
the commonly used drugs for the prevention of migraine.
1. This product is inhibition of bradykinin (BK) on the peripheral
nerve pain induced sedation, and antidepressant effect.
2. This product can reduce the ethanol tolerance,can strengthen the
tranquilizer, sedative and tricyclic
Clinical mainly for typical and atypical migraine, can relieve a
symptom, reduce seizure frequency and duration, obvious curative
effect on acute migraine, but no immediate relief, also be tried in
erythromelalgia, angioneurotic edema, chronic urticaria, skin Nick
disease etc.. Another report, pizotifen for carcinoid syndrome
caused by diarrhea and flushing,carotid pain, polycythemia induced
The main medical use for pizotifen is for the prevention of
vascular headache including migraine and cluster headache.
Pizotifen is one of a range of medications used for this purpose,
other options include propranolol, topiramate, valproic acid and
amitriptyline. While pizotifen is reasonably effective, its use is
limited by side effects, principally drowsiness and weight gain,
and it is usually not the first choice medicine for preventing
migraines, instead being used as an alternative when other drugs
have failed to be effective. It is not effective in relieving
migraine attacks once in progress. Pizotifen has also been reported
as highly effective in a severe case of erythromelalgia, a rare
neurovascular disease that is sometimes refractory to the other
drugs named above.
Other applications for which pizotifen may be used include as an
antidepressant, or for the treatment of anxiety or social phobia.
Animal studies also suggest that pizotyline could be used in the
treatment of serotonin syndrome or MDMA overdose in a similar
manner to the closely related antihistamine/ antiserotonin drug
How does this medication work? What will it do for me?
Pizotifen is used to prevent migraine headaches. It is not used to
treat headaches once they have started. It is not known exactly how
this medication works, but it is thought to affect chemicals,
called neurotransmitters, in the brain. It may take up to 4 weeks
for the medication to have its maximum effect.
This medication may be available under multiple brand names and/or
in several different forms. Any specific brand name of this
medication may not be available in all of the forms or approved for
all of the conditions discussed here. As well, some forms of this
medication may not be used for all of the conditions discussed
Your doctor may have suggested this medication for conditions other
than those listed in these drug information articles. If you have
not discussed this with your doctor or are not sure why you are
taking this medication, speak to your doctor. Do not stop taking
this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the
same symptoms as you do. It can be harmful for people to take this
medication if their doctor has not prescribed it.
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